Officials mull seismic tests near Calif. nuke plant

SAN FRANCISCO (AP) ? Plans to use an array of powerful air cannons in an undersea seismic study near a Central California nuclear power plant have federal and state officials juggling concerns over marine life with public safety.

Pacific Gas & Electric Co. wants to use big air guns to emit strong sound waves into a large, near-shore area that includes parts of marine reserves to make three-dimensional maps of fault zones, some of which were discovered in 2008, near its Diablo Canyon nuclear power plant.

But a state study, mandated by AB1632, signed into law in 2006, found the project is likely to have "unavoidable adverse effects" on marine life and the environment. Biologists, environmental groups and fishermen have opposed using the high-energy air guns, saying the blasts have potential to harm endangered whales, California sea otters and other creatures frequenting these waters.

"I am very concerned about impacts to marine mammals, especially some of the large whales including blue, fin, and humpback whales," said John Calambokidis, an Olympia, Wash.-based marine biologist who has studied Pacific Ocean whales for decades. "There are many uncertainties on the impact of this type of operation on whales, especially since we have not seen this type of large air gun survey off California for a long time."

The $64 million, ratepayer-funded effort to understand seismic threats to the plant has intensified since the disastrous 2011 Tohoku quake and tsunami, which disabled reactors at Japan's Fukushima Dai-ichi nuclear power plant. Quake experts were surprised by the 9.0-magnitude quake on a fault that scientists did not believe would produce a quake stronger than 8.0.

Although the Japan disaster demonstrated that predicting the strength of a quake on a given fault is an inexact science, PG&E wants to know if the newly discovered faults near San Luis Obispo are connected to existing ones that have already been studied. Seismologists typically use a fault's length to estimate the maximum possible earthquake it can produce.

"People need to understand, we're living in the world post-Fukushima, so we need to go back and review everything we think we know about the seismic threat situation around important structures like this power plant," said Bruce Gibson, a former seismologist who now serves as a San Luis Obispo County supervisor.

"Unfortunately, from an environmental impact standpoint, the only real way to get the images is to put high energy sound into the earth."

If the project gains approval from myriad agencies, scientists would tow up to 18 air guns behind a boat and blast loud sound into the water over a 530-square-nautical-mile area. Hundreds of sensors would be placed strategically on the seafloor, picking up the reverberations and allowing computers to create three-dimensional maps in technology similar to an ultrasound.

The air guns and sensors would be dragged through an area that includes two state marine protected areas ? Cambria and White Rock ? and is adjacent to the Monterey Bay National Marine Sanctuary. Dozens of endangered and threatened species use these waters.

A similar seismic survey is being planned near the state's other nuclear plant at San Onofre, in San Diego County to the south.

A State Lands Commission environmental impact study found on Aug. 20 there would be "unavoidable impacts" to marine life in the area during the San Luis Obispo testing.

But the commission also concluded the "benefit of the project outweighs the unavoidable adverse impacts," said Jennifer DeLeon, a senior environmental scientist at the commission.

While similar high energy seismic surveys have been done on the Pacific Coast ? most recently off Washington ? PG&E said monitors there did not observe harm to whales or other marine mammals.

The powerful cannons used in these projects can be fatal to animals that stray too close to them. Also, biologists said the loud noises could drive migrating whales and their calves apart, and that mortally wounded whales often sink in the ocean, so it is difficult to see how the tests affect the creatures.

Efforts to mitigate such impacts will reduce, but not eliminate, harm to animals, according to the company and earth scientists.

"The sound source for the PG&E imaging project is a type that has been used for several decades by scientists and industry," Donna Blackman, a geophysicist at Scripps Institution of Oceanography in San Diego, said in an email. "Known cases of possible impacts on marine mammals are very few. An integral part of using this type of system is to have continuous monitoring for whales within close range of the ship."

PG&E said it is spending $8 million on monitoring for the project, said Mark Krausse, a PG&E director.

"If the ship is coming within 1.1 mile of any mammal, not just a marine or listed, but any mammal, we have to shut down," Krausse told the California Fish and Game Commission on Monday.

PG&E wanted to start work Nov. 1 and continue through Dec. 31 ? a time window believed to have lower whale traffic off the Central Coast. But the company has asked for an extension of its hearing before the California Coastal Commission, and other agencies are not expected to approve testing permits by then.

Major environmental groups such as the Sierra Club and Natural Resources Defense Council oppose the plan, saying adequate seismic research already has been done, and that too little is understood about potential long-term impacts of the air guns on the marine environment.

"The marine protected areas were created (so) marine wildlife could thrive without human interference," said Amanda Wallner of Sierra Club California. "We share concern over earthquake risk at Diablo Canyon. However, we don't believe this is the best way or the only way to determine seismic risks."

Source: http://news.yahoo.com/officials-mull-seismic-tests-near-calif-nuke-plant-150645033.html

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Moffitt Cancer Center researcher helps develop prostate cancer testing

Julio M. Pow-Sang, M.D., chair of Moffitt Cancer Center's Department of Genitourinary Oncology, and colleagues have published two prostate cancer articles in the September issue of JNCCN ? The Journal of the National Comprehensive Cancer Network. The articles review and clarify recent updates made to the National Comprehensive Cancer Network's (NCCN) guidelines for the screening and treatment of prostate cancer.

According to the NCCN, nearly 242,000 cases of prostate cancer will be diagnosed in 2012, accounting for 29 percent of new cancers among men. It is estimated that more than 28,000 men will die from the disease this year.

According to the journal, prostate cancer is "over diagnosed and over treated" and is subject to a controversy "fueled by large screening studies." This month, Prostate Cancer Awareness Month, the NCCN has offered support for active surveillance, a strategy by which men with low-risk tumors, often classified as clinically insignificant, are monitored over time.

"Depending on the disease characteristics and the patient's life expectancy and personal preference, active surveillance may be a viable alternative to immediate and radical treatment," Pow-Sang said. "For others with high-risk, localized tumors or locally advanced disease, there are recent treatment advances that should be considered."

New agents and therapy combinations

According to the NCCN, external beam radiation and androgen deprivation therapy have been the traditional treatments for patients with high-risk tumors. However, the NCCN reports that brachytherapy, either permanent seed implant or temporary placement (high dose radiation), combined with external beam radiation and androgen deprivation therapy is increasingly being used for these patients.

The first article, Prostate Cancer, version 3.2012, noted that two new agents ? abiraterone acetate and immunotherapy sipuleucel-T ? are welcome therapeutic additions for patients with late-stage disease and poor prognosis.

Abiraterone acetate, which inhibits a key enzyme related to prostate cancer, can be given to patients after their chemotherapy. Studies have shown that it can also be used in chemotherapy-na?ve patients.

Sipuleucel-T, a second line therapy, is a live cancer vaccine approved in 2010 for treating asymptomatic or minimally symptomatic patients with metastatic prostate cancer. The NCCN has recommended the new drug for use after chemotherapy failure or as treatment along with chemotherapy.

"The new NCCN guidelines highlight important updates to the management of prostate cancer," concluded Pow-Sang and his co-authors. "These protocols are updated annually and more often when new, high-quality clinical data become available. The guidelines are based on evidence from clinical trials combined with expert consensus."

Active surveillance and PSA density, percent free, and biopsy cores

In a second article, Enrollment Criteria Controversies for Active Surveillance and Triggers for Conversion to Treatment in Prostate Cancer, Pow-Sang and co-author David D. Buethe, M.D., a urologic oncology fellow at Moffitt, examine the controversy and criteria for implementing active surveillance for patients with asymptomatic prostate cancer and identify the triggers that would convert active surveillance patients to active treatment status.

The authors note that for those patients with prostate cancers at low-risk for progression, the active surveillance strategy was proposed a decade ago but is recently receiving more attention as a viable management option.

"However, critical uncertainties still surround active surveillance," Pow-Sang said. "The criteria that qualify a patient as low or very low risk are not clear, nor is the definition of disease progression."

In this article, Pow-Sang and Buethe reviewed recent literature regarding those uncertainties, examining criteria for assisting in selecting men for active surveillance, including PSA density, percent free versus percent total PSA, biopsy positive core results and "volume of involvement" data.

"A PSA density of greater than 0.08 ng/mL/g has been identified as a significant predictor of future disease progression in those with low-risk prostate cancer," reported Pow-Sang. "However, some clinicians use a level of 0.15 ng/mL/g as a threshold."

Percent-free PSA has been found to be a significant predictor of organ-confined disease, said Pow-Sang and Buethe, noting that some reports have shown a significant indirect correlation between percent-free PSA and prostate cancer volume; but as yet this parameter is "not widely accepted as a predictor of cancer extent."

They also looked at studies on positive cores from biopsies and the extent to which core results could be used to develop criteria for treatment. Reports have shown the predictive value of positive biopsy cores, but the frequency for performing prostate biopsies remains controversial for outcomes of active surveillance patients, Pow-Sang said.

"Biopsies are not without consequences," he said. "Rectal bleeding and serious infectious complications from frequent biopsies need to be considered."

Additionally, no standard protocol exists, and controversy remains, for the frequency of PSA testing and the digital rectal exam for patients who are under active surveillance.

"Current guidelines vary," Pow-Sang said. "There are recommendations that the PSA and digital rectal exam should be performed every three to six months, or the PSA every three months and the digital rectal exam every six months. The frequency of biopsies is also variable, from once a year to up to every three years."

New potential tools

Pow-Sang and Buethe also report that a new tool, the PCA3 urinary marker, may be useful. PCA3 is a urine test used to quantify copies of the known prostate cancer gene 3. A PCA3 score of 35 or greater is considered possibly malignant. The test is prostate cancer specific and unaffected by prostatitis or benign prostatic hyperplasia, both of which have confounded the results of PSA testing.

The future of active surveillance

"Most studies report that 30 percent of active surveillance-classified men will be reclassified in the short term to clinically significant cancer that may require treatment," noted Pow-Sang. "Once more, PSA velocity (how quickly the PSA score rises) or PSA doubling time (how often the score doubles) has no clear role in active surveillance."

When counseling men with early prostate cancer, all treatment options, risks and complications should be discussed, Pow-Sang confirmed.

"Active surveillance is a reasonable management strategy for low-risk and very low risk prostate cancer, but allows for continual reassessment and identification of progressive tumors."

Source: http://www.sciencecodex.com/moffitt_cancer_center_researcher_helps_develop_prostate_cancer_testing_treatment_guidelines-99276

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.AU and .IE Announce Funding For Projects To Assist Internet ...

The .AU policy and regulatory body and .IE registry have announced funding for a wide range of projects that are intended to assist the development of the internet in Australia and Ireland respectively.

In Australia, auDA announced their Foundation will fund a PhD thesis that enables Indigenous communities to access and use three dimensional (3D) models of Australian landscapes. Another project that won funding will explore the use of the internet by young people at risk of self-harm or suicide to seek help.

This year twelve projects were awarded a total of A$371,431, including the funding of two three-year PhD scholarships, taking the total number of projects funded to 84 over six annual funding rounds totalling $1,657,769.

?We were delighted by the number of applications we received, many of which were exemplary,? auDA CEO Chris Disspain said in a statement. ?We feel that funding these initiatives could significantly improve the lives of many Australians through their creative use of the internet.?

Meanwhile in Ireland, IEDR?s OPTIMISE Fund announced funding for a total of 15 companies to raise awareness of low levels of e-commerce activity by Irish SMEs and micro-enterprises. The funding also aims to provide practical assistance to a targeted number of companies to upgrade their online presence and grow their business using the internet as a sales channel.

Each of the 15 winners will be provided with practical assistance to begin the process of upgrading their existing online presence to fully featured websites which incorporate e-commerce functionality and other facilities designed to support business development. The intention is that recipients will be better placed to harness the potential of the internet as a 24 hour sales and marketing channel and gain a competitive advantage.

Recipients will also receive up to 11 days professional technical and marketing support to allow them to plan and execute a major e-commerce upgrade.

The winners of both funding rounds are below.

From auDA:

• Hello Sunday Morning
• Prahran Mission UnitingCare
• RMIT University
• Reef Check Foundation
• University of South Australia
• WorkVentures
• University of the Sunshine Coast
• Monash Indigenous Centre, Monash University
• Ballarat City Council
• Guide Dogs Victoria
• Deaf Services Queensland
• Griffith University.

From IEDR:

• Catering Equipment
• IFA Telecom Ltd.
• Waterford Technologies
• Tour America
• Parade Ring
• Just Dance
• Project 51
• Rossmore Furniture
• Gaga Baby Ltd
• Doolin Cave
• Oideas Gael
• OPTICKS SB Ltd
• Morris Oil Co. Ltd.
• Sheridan Insurances Ltd.
• Digital Business Services Ltd.

Source: http://www.domainnews.com/en/au-and-ie-announce-funding-for-projects-to-assist-internet-development.html

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Analysing The Evidence On DNA

Greg Hampikian
Director, Idaho Innocence Project
Professor, Departments of Biological Sciences and Criminal Justice
Boise State University
Boise, Idaho

When police find DNA at a crime scene, the amount and how it's handled are crucial components in solving a case. Greg Hampikian, Director of the Idaho Innocence Project, discusses the use and misuse of DNA analysis, and why he says all DNA evidence is not created equal.

Source: http://www.npr.org/2012/09/28/161955789/analysing-the-evidence-on-dna?ft=1&f=1007

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US immigration chief: Same-sex ties are family ties

By Miranda Leitsinger, NBC News

Same-sex couples will be considered ?family relationships? in immigration proceedings, according to Department of Homeland Security Secretary Janet Napolitano, a move that could help stem the deportation of those in gay or lesbian binational relationships.

Close family ties to the United States are a factor considered by authorities in deportation cases, and gay and lesbian advocates have long argued for same-sex couples to have the same immigration rights as opposite-sex couples.

?In an effort to make clear the definition of the phrase ?family relationships,? I have directed ICE to disseminate written guidance to the field that the interpretation of the phrase ?family relationships? includes long-term, same-sex partners,? Napolitano said in a letter.

Eight-four members of Congress signed a joint letter to Napolitano on July 31 asking for her to put into writing an order to prevent the deportation and separation of immigrants from their American citizen same-sex partners.

?One of those who penned the letter, U.S. Congressman Michael Honda of California, said Napolitano?s response, which he received Thursday night, heralded ?promising news.?

?In the wake of this important victory, we must take a step forward and continue the fight for immigration reform. Current immigration laws are tearing families apart and separating American citizens from their loves ones,? he said in a statement.??No one should have to choose between their spouse and their country, and no family should be left out of the immigration system.?

Gay couples, where spouse is a foreigner, sue over DOMA
Same-sex couple fights to stop deportation, gay marriage ban
For some gay couples, fight goes on to marry ? and stay in the US

There are an estimated 36,000 binational gay couples in the U.S. Two such couples have brought lawsuits challenging the Defense of Marriage Act, a U.S. law passed in 1996 that bars federal recognition of same-sex marriages and thereby denies various benefits given to heterosexual couples, such as the right to immigrate.

Rachel B. Tiven, executive director of Immigration Equality, called the announcement a ?huge step forward.?

?Until now, LGBT families and their lawyers had nothing to rely on but an oral promise that prosecutorial discretion would include all families. Today, DHS has responded to Congress and made that promise real. The Administration?s written guidance will help families facing separation and the field officers who are reviewing their cases,? she said in a statement.

Tiven was referring to the prosecutorial discretion laid out in June 2011, when ICE Director John Morton issued a memo requiring staff? to consider the circumstances presented in individual deportation cases, such as whether the person has close family ties to the U.S.

More content from NBCNews.com:

Follow US News from NBCNews.com on Twitter and Facebook

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Source: http://usnews.nbcnews.com/_news/2012/09/28/14140024-us-immigration-chief-same-sex-ties-are-family-ties?lite

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UK Newsx.com ? Small Techniques Aaron Rodgers Elite Jersey To ...

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Source: http://www.uknewsx.com/small-techniques-aaron-rodgers-elite-jersey-to-assist-you-to-make-your-self-improvement-exceptional/

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Public Speaking Tips To Help You Shine - Cordoba Luxury Rentals

Have you ever found yourself facing a room of people, full of nervousness about how to address them and hold their attention? If you?re like most of us, you probably experience at least a few rushes of public-speaking jitters when you have to talk in front of a crowd. Here are some tips to make your next public-speaking occasion as effective and anxiety-free as possible:

?

Know Your Material

This is perhaps the most central key to effectively addressing a group of people. If you have any doubts about the material at hand or any uncertainties about your own grasp of it, your level of anxiety will be high ? and, of course, the more nervous and lacking in confidence you are, the more likely you are to come across as a weak and ineffectual public speaker. So it is crucially important to review your material extensively and practice your presentation as thoroughly as possible so that you can walk in the room relaxed and confident in the conviction that you know your stuff.

?

Know Your Audience

Before you prepare your presentation, make sure you know your audience. Have a strong grasp of their interests and their reasons for being attendance at your public speaking occasion. Also make sure you keep in mind the general tone of the event and group of people ? is it an informal talk to a bunch of people with similar interests, a serious and formal business presentation, or a presentation for a crowd who will want there to be a high entertainment factor? When it comes to the topic you?re addressing, will you be speaking to a group of specialists on that topic or non-specialists without much background in the area? Knowing as much as you can about the audience will help you design a presentation effectively geared toward them.

?

Be Conscious of Speed?

One of the biggest mistakes that novice public speakers do is talk at a very rapid pace. This quickness can come from nervousness or just from a sense that there isn?t enough time to fit in all the necessary information. So it is important to make sure you slow down when speaking, giving your audience time to absorb what you have said (and also giving note-takers a chance to write things down). Along those same lines, make sure you have designed your presentation so that you?re not trying to squeeze too much information into too short an amount of time. Practice it several times and restructure it or cut out sections if it needs shortening. You will be much more comfortable and relaxed if you?re not worrying, throughout your presentation, that you might not fit it all in if you don?t go fast enough.?

?

Be Present

A truly effective public speaker makes the audience feel as if they are being seen, spoken to, and heard, so you want to give the impression of being tuned into the people in the room. An important way of doing this is to maintain sincere eye contact; looking around the room and meeting people?s eyes (for no more than roughly 3 seconds) has been proven as a strong method of connecting with your audience. You want to look at them, not around or above them. In addition, if one of them poses a question, make sure you really listen and respond in a way that is as individually geared toward the person and the question as possible ? the key to being able to do this is to know your material so well that you are able to remain flexible and adaptable, able to navigate the situation in a natural manner rather than having to stick to rigid notecards.

?

Speak With Conviction

If you speak as if you are passionate about and committed to what you are saying, people won?t likely notice if you make a few gaffes along the way. Your ability to hold the audience?s interest and convince them of the ideas you?re presenting has a lot to do with how much you convey your own sense of belief in those ideas. So be aware of using your vocal tones, your facial expressions, and your body language as tools to convey conviction and enthusiasm and also as powerful mediums of persuasion. Another way to communicate your passion and belief in what you?re presenting is through the basic act of putting together a really strong presentation ? if you come in with a highly organized, well thought-out, and articulate presentation, your audience will know they are in the presence of someone who cares about what he or she is saying.?

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Source: http://cordobadoralblog.com/2012/09/27/public-speaking-tips-to-help-you-shine/

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Passenger accused of grabbing women on flight restrained

Featured

4 hrs.

A. Pawlowski , NBC News contributor

As another dog owner mourns the death of his pet after a?flight, there?s growing concern about the safety of beloved furry companions in?th... Read more

1 day

Robert Kovacik and Jonathan Lloyd

Passengers used belts to restrain a man who was taken into custody Tuesday night after allegedly harassing people ? including a woman who said he grabbed her hair and asked her to kiss him???aboard a flight from Chicago to Santa Ana, Calif.

Passenger Nona Pitts told NBC4 in Southern California that the man, identified by the FBI as 26-year-old actor-model Arash Durrani, sat across from her on United Airlines Flight 473. Pitts asked whether he was "on anything" because of his strange behavior.

This story originally appeared on NBCLosAngeles.com.

"He was kind of slurring his words," Pitts said. "He just goes, 'Why, you want some?'"

"The stewardess came by and he said, 'I want another (Jack Daniels),'" she said. Pitts told the flight attendant she thought the man had enough to drink, but said he received "two more bottles of J.D."

Pitts, who owns an Orange County, Calif. salon, moved to a different seat, but Durrani followed her, she said.

"He grabs my hair and he goes, 'Nona, Nona, Nona, kiss me,'" said Pitts.

When the man started pacing and scaring children on the plane, passenger David Truong said he and other passengers took action and physically restrained the man with belts.

"He looked at every one of us and said, 'I'm going to kill you and your entire family,'" Truong said.

The man was restrained for nearly three hours.

More from NBCLosAngeles.com:

Durrani, who also goes by "Ash," is listed as an actor in one movie that hasn't been released. His agent, Sheila Di Marco, said Wednesday she hadn't heard anything about the incident.

Durrani will be charged with a federal offense for interference with a flight crew, FBI spokeswoman Laura Eimiller said.

Durrani used to reside in Costa Mesa but now lives in Virginia. He was due back in Southern California for a criminal court appearance, according to the FBI.

More on Overhead Bin:

Source: http://overheadbin.nbcnews.com/_news/2012/09/27/14125491-passengers-restrain-man-accused-of-grabbing-women-on-united-flight?lite

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Inquest into death of Jacob Michael in police custody in Runcorn to ...

27 September 2012

9.30am, Monday 1 October 2012
Daresbury Park Hotel, Warrington, Cheshire, WA4 4BB
Before HM CoronerThe legal official who orders a post-mortem and who is in charge of the inquest procedure. Nicholas Rheinberg

The inquest into the death of Jacob Michael will begin on Monday 1 October at the Daresbury Park Hotel in Warrington.

Jacob Michael died on 22 August 2011 aged 25 following arrest and restraint by police.? He had called the police himself in an agitated state after telling his family he had been threatened.? The police arrived at the house and forced their way into his bedroom, spraying incapacitant spray at him, whereupon Mr Michael ran out of the house and down the street.? The police pursued him, striking him with batons and restraining him before putting him in the back of a police van to take him into custody at Runcorn police station.

He was then left face down on the floor of a police cell for several minutes with police officers standing on his legs, where he died.

On the first day of the inquest, the jury will be shown disturbing CCTV film of Jacob Michael being pursued by police officers wielding batons in the street outside his home, being transported in the police van, arriving at the custody suite and then being held face down on the cell floor where he died.? More than 60 witnesses are listed to give evidence including Jacob?s mother, civilian eye witnesses and police officers.? The inquest is scheduled to last for four weeks.

Jacob Michael?s family hope the inquest will answer serious questions concerning the officers? actions when they entered his bedroom, the use of force by police in the street, the restraint itself, the failure to treat him as a medical emergency rather than take him to the police station, his treatment in the police station, and the overall attitude of police to a young man who was clearly confused, frightened and unwell.

Ann Michael, Jacob Michael?s mother said:

?My son called the police for help and they sprayed him with pepper spray and arrested him.? Two hours later there was a knock on my door by the police to say that he had passed away.? He was a fit twenty five year old man.? I want to know why.? I just can?t understand it.?

Deborah Coles, INQUEST co-director said:

?Yet again, we begin an inquest into a death following restraint in police custody of a young black man.? This is a particularly disturbing and distressing death, made all the more so by the existence of CCTV footage for much of his last minutes alive.? Serious questions must be asked about how a young man in distress came to be hit with batons, restrained, and disregarded while he lay dying on a police cell floor.

?It is vital both for Jacob Michael?s family and the public that this is a far reaching and thorough inquest into his death.?

Kate Maynard, solicitor instructed by the family, said:

?The family and the local community need to know how and why Jacob died in police hands. The family feels that the IPCC had not adequately investigated Jacob?s death and they now look to the inquest proceedings to get the answers they need?.

The family is being represented by INQUEST Lawyers Group members Adam Sandell of Matrix Chambers, instructed by Kate Maynard of Hickman & Rose Solicitors.

Ends

Source: http://inquest.gn.apc.org/website/press-releases/press-releases-2012/inquest-into-death-of-jacob-michael-in-police-custody-in-runcorn-to-begin-monday-1-october

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Acupuncture is more than a placebo for chronic pain

Acupuncture may go more mainstream now that new research shows that it provides modest but statistically significant benefits over both standard care and placebo for patients with chronic pain.

A team led by researchers at Memorial Sloan-Kettering Cancer Center in New York looked at 29 randomized controlled trials involving a total of 17,922 people from the U.S., Germany, Spain, and Sweden who suffered with back and neck pain, osteoarthritis, or chronic headaches. For greater precision, the investigators analyzed data on the individual patients, rather than outcome summaries, as prior reviews have done. The study was published online Sept. 10 by Archives of Internal Medicine.

In 18 of the studies, patients either got acupuncture, in which needles were inserted at points of the body traditionally used to provide pain relief, or standard treatments such as analgesics, physical therapy and exercise. In 11 others, acupuncture was compared with a control group that included "sham" acupuncture, in which needles didn't break the skin or were inserted superficially.

The meta-analysis showed that patients who received real acupuncture had less pain than those who got standard care or sham acupuncture. However, the differences between true and sham acupuncture were relatively modest.

While the data "indicate that acupuncture is more than a placebo," according to the report, patients who believe that acupuncture will be effective may derive some placebo-based benefit.

Bottom line: The results provide the best evidence to date that acupuncture is a reasonable option for people with chronic pain. If you decide to try acupuncture, talk with your physician first to set realistic expectations for improvement. Our recent survey of subscribers to Consumer Reports found that many derived benefit from acupuncture and other alternative therapies for 12 common health problems. See our full report on alternative therapies, including advice on how to find a good acupuncturist. If you and your doctor decide that you need prescription help, see our Best Buy Drugs report on treating chronic pain.

Source

Acupuncture for chronic pain [Archives of Internal Medicine]

Source: http://news.consumerreports.org/health/2012/09/acupuncture-is-more-than-a-placebo-for-chronic-pain.html

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Nine Bridges to Cross in Business Development for Accounting Firms

Eyes wide open, forging ahead.

by Nick Keseric

Nick Keseric

On our summer family vacation last month, we traveled through the east coast and I can?t recall a time when we crossed over more bridges. Some bridges were old, some were brand new, some low and some very high. And with each crossing, my wife would sink deeper into the passenger seat with eyes closed while our kids pointed out some of the sights only seen at higher elevations thanks to the bridge. Too bad Pam didn?t get a chance to see those sights.

I?m not sure, but my wife might have gephyrophobia, the fear of crossing bridges.

More on business development from Nick Keseric:?If Business Development Is a Circus at Your Firm??? |? My Attitude??? What?s Wrong with My @#$%! Attitude?? |? Curious Minds Want to Know: Are You Helping or Selling?? |? The Six-Step Roadmap for CPA Change Agents? |? 20 Biz Dev Ideas for Your Career and Your Firm? |

In business development, if we have gephyrophobia, we shouldn?t be in business development. In business development we need to cross various bridges in the sales and marketing process each and every day.

In order to increase our revenues, development new clients, maintain current clients and cultivate referral sources, we may want to look at few of these bridges we will need to cross? without eyes closed or sinking into our chair behind our desk:

1. Bridge of Adoptability : Given the competition by quality firms in the accounting profession, there is the greater ?need to look to adopt to the needs of our prospects and clients more so than ever and not only in pricing. Just saying, ?We don?t do that? could be the last thing you say to a longtime client. Seek out ways to cross over to get what they want completed. Creativity. Innovation. And yes, the old, ?think outside the box? to get the job completed.
2. Bridge of Communications:? Both internally to colleagues and externally to prospects, clients and referral sources. Let others know what is going on. Keep them informed? not surprised.
3. Bridge of Information: Be the source of answers and solutions directly or incorporate a colleague who can assist your clients, prospects and or referral sources with their questions.? By bringing in a colleague, you are showing the teamwork approach within your firm. You can say it, but when you demonstrate, it becomes more powerful.
4. Bridge of Technology: While a face to face meeting is hard to beat for business development, being aware of the latest technology used in business development is no longer a luxury? it is a necessity. Keep updated of that is available. Pagers. Car phones. Remember them? All had their day but technology evolves.
5. Bridge of Enthusiasm: Perception. It?s all about being welcoming and the willingness to help. We alone control this. Not a marketing or business plan. Our spirit inside of us controls how we project ourselves as well as our firm to others. Being positive sells.
6. Bridge of Trust: In order to convert prospects into clients, there needs to be trust. And while everyone will have their own definition of trust, the end-results are the same. There is something that occurs over a period of time that you conveyed or did something to a prospect that they feel confident (trust) with you and your firm.
7. Bridge of Connections:? This is your network. Each day try to grow your network as you never know when you may need that person and their expertise. Be visible in your business community and your own community. Be seen and be heard.
8. Bridge of Determination: Business development is not easy and is filled with detours of unanswered voicemails, tossed out letters, deleted emails, cancelled meetings and having to pick yourself off of the ground. But your determination will bring you closer one thing? success.
9. Bridge of Follow Up: If you don?t cross this bridge, all of your travels towards a prospect, client or referral source were wasted. The bridge of follow up is your main route to new revenues.

If firms don?t cross over these and other bridges in business development like growing accounting firms do, the prospects, clients or referral sources may indeed think your firm has gephyrophobia and view your firm as: CAUTION ? BRIDGE OUT.

?

Nick Keseric is director of practice growth for the Orland Park, Ill., accounting firm MPS and a member and director of marketing development for MPS Capital Advisors LLC, at www.mpscpa.com

?

Posted September 26, 2012
Related Topics: Sales

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Source: http://cpatrendlines.com/2012/09/26/nine-bridges-to-cross-in-business-development-for-accounting-firms/

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Video: Organizational failures run deep for Saints

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Source: http://nbcsports.msnbc.com/id/21134540/vp/49198011#49198011

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How Survival Doomsday Preppers Stock Up for Emergency ...

You can have heard that will December 12, Next year may be the end in the world. Whether this is or otherwise not, there are many people that they call themselves emergency doomsday preppers. This doesn?t imply they are going to appear to be military men wearing camouflage clothing uniforms and waiting for the end of the world in advance. Preppers are ordinary folks; he may become your next door neighbor or maybe your doctor. Any individual could be a prepper and most ones should not be known that they?re preppers even though some get their very own group preparing by themselves for your ?End from the World?.

To put it briefly, survival doomsday preppers are generally individuals who store food, equipment and other requirements in case disaster comes about. Disasters happens to be an earthquake, tornado, hurricane, large economic downfall, petrol leak or perhaps a flames. It can be something that would certainly require a person or a family to leave. Preppers are people who consider everything seriously as well as would like to maintain stocks of precisely what can keep them alive for a few days, weeks, a few months or for per year. These people maintain stocks of food, h2o, blankets, flashlights, tools along with a generator that can let them have heat and light in case of the crisis days.

The standard success doomsday preppers fears about the end around the globe along with situations in which the breakdown of law is unrestrained. Additionally they fear monetary downfall of these country and possible war of the country against one more nation. The preppers main objective will be the security of his family members and for this reason, he could be built with survival firearms. For these people, you?ll find nothing incorrect with being prepared for the forthcoming ?end through the world? or if the nation is within deep financial difficulties. Most preppers manage to get thier creativity and information from the web or even using their group where they exchange e-mail to update themselves on the news about the preppers.

The preppers of the olden instances are very not the same as the preppers we have today. Many of the preppers we now have today tend to be silent individuals who would you have imagined they could be preparing for the worst type of. They turn their own spare room right pantry and train the people in themselves tactical techniques. Many of these everyone has exactly the same believing that economic destruction is arriving soon and all they want to gain would be to come well prepared. The advantage of the emergency doomsday preppers, they don?t arranged a particular date for your forthcoming destruction. All they want to gain is to be prepared. To deal with many things can happen anytime of the day plus it might not harm them whenever they come ready for the worst scenario. Of such people, nobody may predict the most severe but right now they?ve got the gut experience the time is coming shortly.

For more information about preppers please visit the website.

Written by: DelorisHSchilling on 2012/09/25.

Source: http://www.articletops.com/computers-technology/how-survival-doomsday-preppers-stock-up-for-emergency-2.html

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What can the water monster teach us about tissue regeneration in humans?

Public release date: 25-Sep-2012
[ | E-mail | Share ]

Contact: Andy Hoang
ahoang@salk.edu
619-861-5811
Salk Institute

Understanding how salamanders grow new limbs provides insights into the potential of human regenerative medicine

LA JOLLA, CA---- Based on two new studies by researchers at the Salk Institute for Biological Studies, regeneration of a new limb or organ in a human will be much more difficult than the mad scientist and supervillain, Dr. Curt Connors, made it seem in the Amazing Spider-man comics and films.

As those who saw the recent "The Amazing Spiderman" movie will know, Dr. Connors injected himself with a serum made from lizard DNA to successfully regrow his missing lower right arm - that is, before the formula transformed him into a reptilian humanoid.

But by studying a real lizard-like amphibian, which can regenerate missing limbs, the Salk researchers discovered that it isn't enough to activate genes that kick start the regenerative process. In fact, one of the first steps is to halt the activity of so-called jumping genes.

In research published August 23 in Development, Growth & Differentiation, and July 27 in Developmental Biology, the researchers show that in the Mexican axolotl, jumping genes have to be shackled or they might move around in the genomes of cells in the tissue destined to become a new limb, and disrupt the process of regeneration.

They found that two proteins, piwi-like 1 (PL1) and piwi-like 2 (PL2), perform the job of quieting down jumping genes in this immature tadpole-like form of a salamander, known as an axolotl - a creature whose name means water monster and who can regenerate everything from parts of its brain to eyes, spinal cord, and tail.

"What our work suggests is that jumping genes would be an issue in any situation where you wanted to turn on regeneration," says the studies' senior author, Tony Hunter, a professor in the Molecular and Cell Biology Laboratory and director of the Salk Institute Cancer Center.

"As complex as it already seems, it might seem a hopeless task to try to regenerate a limb or body part in humans, especially since we don't know if humans even have all the genes necessary for regeneration," says Hunter. "For this reason, it is important to understand how regeneration works at a molecular level in a vertebrate that can regenerate as a first step. What we learn may eventually lead to new methods for treating human conditions, such as wound healing and regeneration of simple tissues."

The research team, which included investigators from other universities around the country, sought to characterize the transcriptional fingerprint emerging from the early phase of axolotl regeneration. They specifically looked at the blastema, a structure that forms at a limb's stump.

There the scientists found transcriptional activation of some genes, usually found only in germlime cells, which indicated cellular reprogramming of differentiated cells into a germline state.

In the Development, Growth & Differentiation study, the research team, led by Wei Zhu, then a postdoctoral researcher in Hunter's laboratory, focused on one of these genes, the long interspersed nucleotide element-1 (LINE-1) retrotransposon.

LINE-1 elements are jumping genes that arose early in vertebrate evolution. They are pieces of DNA that copy themselves in two stages - first from DNA to RNA by transcription, and then from RNA to DNA by reverse transcription. These DNA copies can then insert themselves into the cell's genome at new positions.

A few years ago, Fred Gage, professor in the Laboratory of Genetics at the Salk Institute, discovered that LINE-1 elements move around during neuronal development, and may program the identities of individual neurons.

"Most of these copies appear to be 'junk' DNA, because they are defective and can never jump again," says Hunter. But all mammals, including humans, still have active LINE-1 genes, and the salamander, whose genome is 10 times larger than a human's, contains many more.

Active LINE-1 retrotransposons can keep jumping, and that was true in the developing blastema where LINE-1 jumping was dramatically switched on. But in the researchers' companion study, in Developmental Biology, they found that PL1 and PL2 switch off transcription of repeat elements, such as LINE-1. "The idea is that in the development of germ cells, you definitely don't want these things hopping around," says Hunter. "The mobilization of these jumping genes can introduce harmful genomic rearrangements or even abort the regeneration process."

In fact, when the researchers inhibited PL1 and PL2 activity in the axoloti limb blastema, regeneration was significantly slowed down.

"The need to switch on one set of genes to stop other genes from jumping just illustrates how amazingly difficult it would be to regenerate something as complex as a limb in humans," Hunter says. "But that doesn't mean we won't learn valuable lessons about how to treat degenerative diseases."

###

The work was supported by grants from the National Cancer Institute, the U.S. Public Health Service, and an Innovation Grant from the Salk Institute.

About the Salk Institute for Biological Studies:

The Salk Institute for Biological Studies is one of the world's preeminent basic research institutions, where internationally renowned faculty probe fundamental life science questions in a unique, collaborative, and creative environment. Focused both on discovery and on mentoring future generations of researchers, Salk scientists make groundbreaking contributions to our understanding of cancer, aging, Alzheimer's, diabetes and infectious diseases by studying neuroscience, genetics, cell and plant biology, and related disciplines.

Faculty achievements have been recognized with numerous honors, including Nobel Prizes and memberships in the National Academy of Sciences. Founded in 1960 by polio vaccine pioneer Jonas Salk, M.D., the Institute is an independent nonprofit organization and architectural landmark.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 25-Sep-2012
[ | E-mail | Share ]

Contact: Andy Hoang
ahoang@salk.edu
619-861-5811
Salk Institute

Understanding how salamanders grow new limbs provides insights into the potential of human regenerative medicine

LA JOLLA, CA---- Based on two new studies by researchers at the Salk Institute for Biological Studies, regeneration of a new limb or organ in a human will be much more difficult than the mad scientist and supervillain, Dr. Curt Connors, made it seem in the Amazing Spider-man comics and films.

As those who saw the recent "The Amazing Spiderman" movie will know, Dr. Connors injected himself with a serum made from lizard DNA to successfully regrow his missing lower right arm - that is, before the formula transformed him into a reptilian humanoid.

But by studying a real lizard-like amphibian, which can regenerate missing limbs, the Salk researchers discovered that it isn't enough to activate genes that kick start the regenerative process. In fact, one of the first steps is to halt the activity of so-called jumping genes.

In research published August 23 in Development, Growth & Differentiation, and July 27 in Developmental Biology, the researchers show that in the Mexican axolotl, jumping genes have to be shackled or they might move around in the genomes of cells in the tissue destined to become a new limb, and disrupt the process of regeneration.

They found that two proteins, piwi-like 1 (PL1) and piwi-like 2 (PL2), perform the job of quieting down jumping genes in this immature tadpole-like form of a salamander, known as an axolotl - a creature whose name means water monster and who can regenerate everything from parts of its brain to eyes, spinal cord, and tail.

"What our work suggests is that jumping genes would be an issue in any situation where you wanted to turn on regeneration," says the studies' senior author, Tony Hunter, a professor in the Molecular and Cell Biology Laboratory and director of the Salk Institute Cancer Center.

"As complex as it already seems, it might seem a hopeless task to try to regenerate a limb or body part in humans, especially since we don't know if humans even have all the genes necessary for regeneration," says Hunter. "For this reason, it is important to understand how regeneration works at a molecular level in a vertebrate that can regenerate as a first step. What we learn may eventually lead to new methods for treating human conditions, such as wound healing and regeneration of simple tissues."

The research team, which included investigators from other universities around the country, sought to characterize the transcriptional fingerprint emerging from the early phase of axolotl regeneration. They specifically looked at the blastema, a structure that forms at a limb's stump.

There the scientists found transcriptional activation of some genes, usually found only in germlime cells, which indicated cellular reprogramming of differentiated cells into a germline state.

In the Development, Growth & Differentiation study, the research team, led by Wei Zhu, then a postdoctoral researcher in Hunter's laboratory, focused on one of these genes, the long interspersed nucleotide element-1 (LINE-1) retrotransposon.

LINE-1 elements are jumping genes that arose early in vertebrate evolution. They are pieces of DNA that copy themselves in two stages - first from DNA to RNA by transcription, and then from RNA to DNA by reverse transcription. These DNA copies can then insert themselves into the cell's genome at new positions.

A few years ago, Fred Gage, professor in the Laboratory of Genetics at the Salk Institute, discovered that LINE-1 elements move around during neuronal development, and may program the identities of individual neurons.

"Most of these copies appear to be 'junk' DNA, because they are defective and can never jump again," says Hunter. But all mammals, including humans, still have active LINE-1 genes, and the salamander, whose genome is 10 times larger than a human's, contains many more.

Active LINE-1 retrotransposons can keep jumping, and that was true in the developing blastema where LINE-1 jumping was dramatically switched on. But in the researchers' companion study, in Developmental Biology, they found that PL1 and PL2 switch off transcription of repeat elements, such as LINE-1. "The idea is that in the development of germ cells, you definitely don't want these things hopping around," says Hunter. "The mobilization of these jumping genes can introduce harmful genomic rearrangements or even abort the regeneration process."

In fact, when the researchers inhibited PL1 and PL2 activity in the axoloti limb blastema, regeneration was significantly slowed down.

"The need to switch on one set of genes to stop other genes from jumping just illustrates how amazingly difficult it would be to regenerate something as complex as a limb in humans," Hunter says. "But that doesn't mean we won't learn valuable lessons about how to treat degenerative diseases."

###

The work was supported by grants from the National Cancer Institute, the U.S. Public Health Service, and an Innovation Grant from the Salk Institute.

About the Salk Institute for Biological Studies:

The Salk Institute for Biological Studies is one of the world's preeminent basic research institutions, where internationally renowned faculty probe fundamental life science questions in a unique, collaborative, and creative environment. Focused both on discovery and on mentoring future generations of researchers, Salk scientists make groundbreaking contributions to our understanding of cancer, aging, Alzheimer's, diabetes and infectious diseases by studying neuroscience, genetics, cell and plant biology, and related disciplines.

Faculty achievements have been recognized with numerous honors, including Nobel Prizes and memberships in the National Academy of Sciences. Founded in 1960 by polio vaccine pioneer Jonas Salk, M.D., the Institute is an independent nonprofit organization and architectural landmark.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-09/si-wct092512.php

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15 Secrets of Online Dating for Grownup Women: Part 3 ...

Here?s the second article (Part 2 of 3) from my friend and top? Dating coach Bobbi Palmer:

As a dating and relationship coach for women over 40, I encourage my clients to get online. If you are a woman over 40 looking for love I want you online too.

I met my husband online and got married for the first time at the age of 47! And you can too.
But before you put yourself out there, I?ve given you some advice about how to show up, set your expectations, stake your claim, have some fun, and ultimately find a loving partner

(This is a 3 part article, so read Part One and Part Two first if you haven?t already.)

The new hot spot.

Online dating is the new hot spot for boomers and older adults. As a woman over forty, you need to do a little extra work. But like me, you can meet your dream man.

In Part 3 of: 15 Secrets to Successful Online Dating for Grownup Women here are 5 more things to know before you get started:

#11. Be in the moment.

Stop talking to yourself; you are there to talk and listen to him. It?s hard. But being aware is the first step.

When you notice yourself in an over-analytical mode, tell yourself to stop and pay attention to the man sitting in front of you. If you don?t, you may completely miss the man of your dreams.

#12. Don?t be a Fault Finder.

Be kind and practice empathy. He has fears and insecurities just like you. Don?t get hung up on some little thing he does that ?you just can?t live with.?

Consider why he?s doing it, and if it truly is a deal breaker. Then look at him again with the kind eyes of a woman working hard to find a good man.

And regardless of how you end up judging him, always leave him feeling good about himself; even if you?re not going to see him again. You?ll be doing the next woman a favor; and sharing a true kindness to this nice man; even if you?re not planning on seeing him again. Consider it a deposit to your dating karma bank!

#13. Show up on time, looking great.

I know, this seems obvious. But many of us don?t do too well with our punctuality; we just focus on figuring out how to show up during our busy day. Many consider it rude for people to be late. And remember, this is your first and maybe only chance to get that great man to ask you on a date. Focus, and give it the attention it deserves.

Make a plan to be on time, and present yourself as the beautiful woman that you are. If you?re coming from work, leave a few minutes early so you can go home and change out of your power clothes.

If you?re taking a walk with him, don?t even think of wearing your fanny pack and sweats. Dress femininely, and give him your gift of a big open smile. (As a note: if you absolutely hate when people are late, let him know that so he can make an extra effort. That way your date isn?t a lost cause from the first moments.)

#14. Men want women.

Studies show that men are highly attracted to the feminine woman. That doesn?t mean you need to act like a damsel in distress. In fact, that isn?t at all attractive to real grown-up men. Mature men want a woman who is strong and is able to take care of herself; but also willing and able to receive from him.

On your meet date, let the man pay, accept his compliments graciously, and act with loving kindness. In studies, when men are asked why they chose their wives or girlfriends, they consistently identify her ability to receive and extend kindness as attractive feminine qualities.

#15. Have fun while you practice.

Every meeting and date is practice that brings you closer to Mr. I Love You. Statistically, your meet-date won?t turn out to be him. So what?

Enjoy the time and be open to what comes up. Don?t come in with an agenda, and don?t let it ruin your time if, in the first 10 minutes, he doesn?t appear to be your man. Just relax and let yourself enjoy. You never know; you may just let yourself relax into a very nice feeling.

You can also use this as a time to help boost the man?s self-esteem. (Yes, men are as nervous and insecure as we are.). He was nice enough to ?pick you? and make the effort of meeting you. (Remember, as we get older the men have way more choices than we do.)

Unless he?s a real creep (which very very few men are), help him feel good about himself by giving him some compliments and thanking him graciously. Try to learn about him and find what?s unique and interesting. You can learn and gain something from just about anyone.

And Finally?

Ultimately, I learned that the only way to find a lasting and loving relationship is to become a smart, confident and complete woman who merits the love of a good man.

A large part of that journey is being open to learning and having the courage to do new things; even when they are difficult or scary.

If you?re not already online; get there. If you are online, and you haven?t met your special man yet (which I assume you haven?t because you are here), take my advice to heart.

Dating online? The most important thing you need to know?

Having great online dating photos is the single most important thing you can do when dating online, so visit LookBetterOnline and find out why more than 98% of our customers get better dates, and see?how with great profile pictures we can help make your online dating experience successful and more fun than you thought possible!

?

Source: http://blog.lookbetteronline.com/2012/09/15-secrets-of-online-dating-for-grownup-women-part-3/

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Important Things To Know When Buying A Home - Maynas Eric Chua

Real estate agents can help you find a good property and give you a complete list of things that must be done. Don?t forget that many of these experts are the same ones who contributed to the market crash. Before you buy your first property, give these tips a read.

When you officially decide to purchase a home, don?t forget all the other options that are available. Sometimes, the house of your dreams might take what seems like forever to find.

A good tip to use when shopping for a home is to request an itemized checklist from your Realtor. There are many Realtors that have a checklist like this already prepared. It covers the entire home-buying process, from choosing a house to getting a loan. Such a document is a great way to ensure that all details of the transaction are addressed.

TIP! When shopping for your new home, it is important to consider future needs. Take a family, for example.

You need to hire good representation in the form of a real estate agent after deciding to purchase a property. You need one you can trust. Look for an agent with a lot of experience and solid references. Choose an agent carefully after performing due diligence to find one that meets your requirements.

Don?t hire an appraiser unless they have five years experience or more. Avoid hiring an appraiser that a real estate company recommends to you. You will have to deal with conflicting interests. Any appraiser you do hire needs to have a state license and/or be state certified.

Learn as much as you can before you jump into the property market. Many individuals get into the real estate market without thinking things through, and they buy properties that they never should have become involved with. This can cost them time and money. Make sure you know about the market, local incomes, home values and information on the local schools before you make a purchase on a property.

TIP! One of the first things to do when moving into your new home is to make sure you are adequately protected by home insurance. You don?t want to put this off because that?s usually when bad things tend to happen, and you don?t want to have to pay for something out of pocket that insurance would have covered.

If you are considering purchasing a house in a new neighborhood, you should look up information about the neighborhood using resources on the Internet. There is plenty of information available to you, even if you are thinking about moving to a small town. Before you spend money on relocating to a town, make sure you think about the economic situation there.

If you have found a home that you are considering buying, be sure to get online and research the registry for local sex offenders. Although sex offender registries are available to the public, real estate agents are under no obligation to disclose information to potential buyers about registered sex offenders in the neighborhood. Do your own research!

TIP! Figure out the amount of money you can spend on a house by utilizing an online calculator. This handy tool asks you to input your income, debts, and living expenses.

Always do some research about a property before buying. When buying a rental property, there are several key features that you should be looking for. The first thing you need is sustainability. Ask yourself: Is the property?s current condition acceptable? Will it stay acceptable without requiring extensive maintenance? The second aspect to consider when purchasing is the location. Especially with property that you plan to rent, location can make all the difference. Your tenants will want to live somewhere that is close to retailers, service providers, and anywhere else that they travel to often. The third feature is the income demographics, or average income, for the area. This attribute is quite different than just simply looking at location, because it is about high rent areas and low rent areas. Persons in high rent areas are not going to be as concerned with location as persons in areas where rent is lower.

When you are ready to purchase a property, hiring a renowned real estate agent is a must. You can find information about any Realtor through the Better Business Bureau or the Internet. Ask reliable friends and family to get an even better idea of who to trust.

If a home is a real fixer and needs lots of work, you can probably get it for a good price. This allows you to save money up-front, and work on the house at your own rate over an extended period of time. You can build equity in your home while making improvements that maximize its livability for you and your family. Concentrate on placing emphasis on the home?s possibilities instead of its flaws. Ignore the surface imperfections and see if your dream home is peeking out from behind a worn facade.

TIP! If you are looking for piece of property and find one with a view you love, do not overpay just for the view. The view might not be something that is worth it for the next buyer.

You can find a lot of programs to help you with a down payment, search out different ones you might be able to qualify for. Pairing this in conjunction with getting the closing costs covered by the seller can really minimize how many dollars you have to stash away prior to buying a home.

When negotiating a real estate deal, it is wise to prioritize your goals. Get all the issues out in the open and set expectations per each one. Concentrate your energy on getting those issues that are most important to you. You cannot get everything that you want when you negotiate. Flexibility is key to getting the things you really do want.

In the beginning of this article you learned that you should not listen to people who you are not sure of. If experts were so knowledgeable, then why didn?t they do anything to prevent the market from collapsing? You can put less trust in these ?experts? as long as you can learn a little bit about the market. Follow the tips in this article to make sure you take care of all the details when buying a

TIP! You should always make plans to make repairs on a home that is foreclosed. There are a lot of foreclosed homes that have been vacant for an unknown period of time, this means that there has probably been no maintenance during this time.

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Source: http://www.maynaseric.com/important-things-to-know-when-buying-a-home

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Venture firms see signs of rebirth in life sciences

SAN FRANCISCO (Reuters) - Life-sciences and health investing, long shunned by venture-capital investors, is making a comeback.

Several venture firms globally have raised or are raising funds this year in the $200 million to $400 million range dedicated to life sciences, biotech, and medicine, while others have raised large, diversified funds with big chunks dedicated to those fields.

The fundraising builds off a rebound in life-sciences investing last year, when $367.6 million in venture money was invested in healthcare services, up 41 percent from 2010; $2.82 billion went to medical devices and equipment, up 17 percent from 2010; and $4.82 billion went into biotechnology, up 24 percent from 2010.

A handful of big acquisitions, new U.S. laws that could speed up drug approval in key areas, and a broader definition of what investors think belongs in those funds are helping to breathe life into the highly cyclical sector, investors say.

Health and biotechnology start-ups need every boost they can get.

Such companies rarely produce blockbuster initial public offerings. For biotechnology in particular, products have to clear high regulatory hurdles and often take over a decade to get to market. The failure rate is high.

Last year, Morgenthaler Ventures and Advanced Technology Ventures spun off their life-sciences investment teams and merged them into an independent group. Scale Venture Partners said it would stop investing in healthcare.

But the firms that remain in the field say they see hope.

Earlier this year Celgene Corp bought venture-backed drugmaker Avila Therapeutics for $350 million, a price tag that could rise to $925 million if Avila meets certain milestones.

Last year, Daiichi Sankyo bought drugmaker Plexxikon for $805 million, which could rise to $935 million if Plexxikon achieves certain milestones.

Big drugmakers see early-stage venture investing as a proxy for expensive in-house drug development. In part because the relative paucity of venture activity in biotech has raised concerns about the long-term product pipeline, they are increasingly investing directly alongside traditional venture investors.

Established companies "can invest in that innovation with a portion of the dollars they would have invested in their own R&D," said Marty Waters, a lawyer at Wilson Sonsini who helps arrange investments in the area.

Some have set up their own venture funds, as Merck & Co did last year when it created its $250 million Merck Research Venture Fund, joining several other major drugmakers with venture arms.

Those moves are in turn helping to encourage remaining venture-capital firms in the field. This year, the funds raised or being raised include Frazier Healthcare Ventures' $400 million fund, Longitude Ventures' $331 million fund, and a $200 million fund from Index Ventures, GlaxoSmithKline, and Johnson & Johnson.

In addition, generalist firms are raising funds with a heavy life-sciences focus, such as a $600 million fund from Canaan Partners, a $270 million fund from Flagship Ventures, and a $2.5 billion fund from New Enterprise Associates.

Partners say there is a sense that because so many firms have succumbed to the challenges and exited life sciences, the ones that remain will have a better shot at success.

Previously, "too much money was chasing too few deals," said Brent Ahrens of Canaan Partners. "If the too-much-money part goes away, that's likely to improve the ecosystem."

BIG IDEAS, NO GLITZ

Few expect life sciences overall will see the heady gains of the 1990s. And because the field doesn't produce glitzy companies, it will never attract the buzz that a sector such as the consumer Internet has enjoyed in recent years.

"This isn't Facebook or Zynga," said James Topper of Frazier. "Over the past ten years, biotech returns have been steadier than in tech. But you don't have a 100-times fund in biotech like you do in tech," he said, referring to a return of 100 times or more that a few funds have enjoyed as a result of giant scores on companies such as Google and Facebook.

But the different character of life-sciences start-ups is precisely the appeal for many investors. "Every therapeutic idea or product is a big idea," said Kevin Kinsella of Avalon Ventures, which just raised a $200 million life sciences and technology fund. "In technology, until proven otherwise, every idea is a small idea."

Meanwhile, lawmakers and regulators in Washington are working to speed up the approval process for drugs that could lead to breakthroughs in life-threatening diseases - and many investors hope that could in turn speed return on investment.

Some venture firms are also broadening the types of businesses they consider part of the life-sciences field, with ventures that apply information technology to healthcare problems of particular interest.

"There's been more of a consumer-Internet focus," said Annie Lamont of Oak Investment Partners, summing up the attitude as "let's take the consumer Internet and apply it to healthcare."

Oak backs companies such as Castlight, which allows patients to compare costs for medical procedures. The company recently closed a $100 million funding round and is considered an IPO prospect for 2013.

Other venture-backed companies that fit that mold include ZocDoc, which automates appointment booking; 23andMe, a company that allows customers to test and learn about their DNA; and medical-records company Practice Fusion.

Kleiner Perkins Caufield & Byers recently joined Mohr Davidow Ventures, Aberdare Ventures, and the Mayo Clinic as a partner in Rock Health, a program that seeks to foster start-ups that specialize in healthcare-related apps. Rock Health's first class of 35 start-ups graduated last month.

Even traditional healthcare services can sometimes produce venture-capital-style returns. When Universal Health Services acquired psychiatric-facility operator Ascend Health for $500 million in June, Polaris Venture Partners said it stood to earn $115 million, or ten times the firm's investment.

(Editing by Jonathan Weber and Dale Hudson)

(@mcbridesg; sarah.mcbride@thomsonreuters.com; 415 677 2547)

Source: http://news.yahoo.com/venture-firms-see-signs-rebirth-life-sciences-110346505--sector.html

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